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“Prohibitin”g CRAF/MAPK Activation with Rocaglamides

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Presentation on theme: "“Prohibitin”g CRAF/MAPK Activation with Rocaglamides"— Presentation transcript:

1 “Prohibitin”g CRAF/MAPK Activation with Rocaglamides
Krishnaraj Rajalingam, Thomas Rudel  Chemistry & Biology  Volume 19, Issue 9, Pages (September 2012) DOI: /j.chembiol Copyright © 2012 Elsevier Ltd Terms and Conditions

2 Figure 1 Rocaglamides Disrupt PHB-CRAF Interaction Leading to Inactivation of CRAF Kinase Activation of RAS recruits CRAF to the plasma membrane where prohibitin is required for the displacement of from Ser259 to facilitate CRAF activation. PP2A dephosphorylates Ser259, leading to phosphorylation at Ser 338, and dephosphorylates Tyr341, by activating kinases, leading to full activation of CRAF kinase. Rocaglamides directly disrupt PHB1-CRAF interaction, thus, rendering CRAF kinase inactive. Chemistry & Biology  , DOI: ( /j.chembiol ) Copyright © 2012 Elsevier Ltd Terms and Conditions

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