1. Volume 27, Issue 1, Pages 19-34 (January 2011)
Antimicrobial Pharmacokinetic and Pharmacodynamic Issues in the Critically Ill with Severe Sepsis and Septic Shock 
Julie M. Varghese, BPharm (Hons), Jason A. Roberts, PhD, BPharm (Hons), FSHP, Jeffrey Lipman, MBBCh, FCICM, MD 
Critical Care Clinics 
Volume 27, Issue 1, Pages (January 2011)
DOI: /j.ccc
Copyright © 2011 Elsevier Inc. Terms and Conditions

2. Fig. 1
The relationship between pharmacokinetics (PK) and pharmacodynamics (PD).
Critical Care Clinics  , 19-34DOI: ( /j.ccc )
Copyright © 2011 Elsevier Inc. Terms and Conditions

3. Fig. 2
Flow diagram summarizing the effects of pathophysiologic changes on PK/PD parameters of hydrophilic antibiotics. AUC, area under the curve; Cmax, maximum drug concentration; Cmin, minimum drug concentration; CL, clearance; CO, cardiac output; MIC, minimum inhibitory concentration; PK/PD, pharmacokinetic/pharmacodynamic; Vd, volume of distribution.
Critical Care Clinics  , 19-34DOI: ( /j.ccc )
Copyright © 2011 Elsevier Inc. Terms and Conditions

4. Fig. 3
Flow diagram summarizing the effects of pathophysiologic changes on PK/PD parameters of lipophilic antibiotics. AUC, area under the curve; Cmax, maximum drug concentration; Cmin, minimum drug concentration; CL, clearance; CO, cardiac output; MIC, minimum inhibitory concentration; PK/PD, pharmacokinetic/pharmacodynamic; Vd, volume of distribution.
Critical Care Clinics  , 19-34DOI: ( /j.ccc )
Copyright © 2011 Elsevier Inc. Terms and Conditions