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J. Gonçalves-Pereira, A. Martins, P. Póvoa 

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Presentation on theme: "J. Gonçalves-Pereira, A. Martins, P. Póvoa "— Presentation transcript:

1 Pharmacokinetics of gentamicin in critically ill patients: pilot study evaluating the first dose 
J. Gonçalves-Pereira, A. Martins, P. Póvoa  Clinical Microbiology and Infection  Volume 16, Issue 8, Pages (August 2010) DOI: /j x Copyright © 2010 European Society of Clinical Infectious Diseases Terms and Conditions

2 FIG. 1 Relationship between gender and Vd/kg of gentamicin. Women have a significantly higher Vd/kg. Clinical Microbiology and Infection  , DOI: ( /j x) Copyright © 2010 European Society of Clinical Infectious Diseases Terms and Conditions

3 FIG. 2 Time course of gentamicin concentrations on the first day of therapy, assuming a one-compartment pharmacokinetic model and first-order elimination kinetics. The coefficients of variation of Cmax and trough concentration were 0.24 and 1.22, respectively. Target Cmax range is defined by the solid lines (16–24 mg/L). Clinical Microbiology and Infection  , DOI: ( /j x) Copyright © 2010 European Society of Clinical Infectious Diseases Terms and Conditions


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