1. Usage of l‐carnitine antimetabolites for the treatment of HCCl‐Carnitine and metabolites in the l‐carnitine biosynthetic pathway, as well as two essential amino acids, lysine and methionine, necessary for the synthesis of l‐carnitine were identified through our modeling approach.
Usage of l‐carnitine antimetabolites for the treatment of HCCl‐Carnitine and metabolites in the l‐carnitine biosynthetic pathway, as well as two essential amino acids, lysine and methionine, necessary for the synthesis of l‐carnitine were identified through our modeling approach. The analogs of l‐carnitine were proposed as antimetabolites for the treatment of HCC patients and the predicted consequence of the use of an l‐carnitine antimetabolite is presented. l‐Carnitine antimetabolites may result in reduced β‐oxidation, de novo synthesis of fatty acids, and eventually may suppress or kill the growth of the HCC tumor. The abbreviations and the detailed explanations for the metabolites as well as the associated genes for each reaction are presented in HMR 2.0.
Rasmus Agren et al. Mol Syst Biol 2014;10:721
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