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For the Urologist by the Urologist: Essential Concepts in Managing mCRPC.

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Presentation on theme: "For the Urologist by the Urologist: Essential Concepts in Managing mCRPC."— Presentation transcript:

1 For the Urologist by the Urologist: Essential Concepts in Managing mCRPC

2

3 Goals

4 Case Study: Newly Diagnosed Low Volume Metastatic Disease

5 CHAARTED: Benefit of Docetaxel

6

7 Toxicity Grade 3 AE or Greater

8 Treating the Primary Tumor

9 Case Study, Continued

10 Abiraterone COU-AA-302 Trial

11 Enzalutamide PREVAIL Trial

12 Treatment Considerations: Use of Immunotherapy

13 Sipuleucel-T

14 Treatment Considerations: Abiraterone vs Enzalutamide

15 Case Study: mCRPC Progressing Through Second Generation Androgen Axis Inhibitors

16 Further Treatment Considerations

17 Emerging Biomarkers

18 Biomarkers: Mutations of DNA Repair and High Rate of Response to Olaparib

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20 Cabazitaxel

21 Conclusions

22 Remaining Questions


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