1. Hugh B. Fackrell filename : Kuby 01B7
Acquired Immunity
Hugh B. Fackrell
filename : Kuby 01B7

2. Acquired Immunity: Outline
Acquired vs Innate Immunity
Functions of Acquired Immunity
Humoral Immunity: antibody
Cell Mediated Immunity
Role of Macrophages
Regulation of Immunity
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3. Acquired Immunity: Definitions
Antigen
Immunogen
Humoral Immunity
Cell Mediated Immunity
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4. Acquired Immunity: Objectives
Define the following terms: Antigen, immunogen, acquired immunity, humoral immunity, cell mediated immunity
Identify the cells of the acquired immune response from light or electron micrographs
Identify the functions of the cells of the acquired immune reponse
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5. Acquired Immunity Definition Characteristics
Acquired immunity( AKA adaptive immunity) is an altered reactivity to a specific compound after exposure to that compound
Characteristics
Specificity
Memory
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6. Acquired Immunity Important Features
The altered reactivity will not be to all compounds, just those compounds to which the animal has been exposed
The animal has a heightened specific response on second and subsequent exposures because the body ” remembers” previous contacts
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7. Functions of Acquired Immunity
Discriminate between self and non self for:
Defense
destruction of foreign molecules
Homeostasis
removal of dead or damaged cells
Surveillance
control of mutant or cancer cells
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8. Acquired Immunity has Two Forms
Humoral Immunity
lymphocytes react INDIRECTLY on non self molecules via antibodies
Cell Mediated Immunity
Lymphocytes act DIRECTLY on the non self molecules
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9. Lymphocytes

10. combines with products
Immunogen vs Antigen
ANTIGEN: combines with the products of an immune response
IMMUNOGEN:
triggers immunity
and
combines with products

11. Antigen: interaction

12. Remember
Immunogenicity is not an inherent characteristic of a molecule
Immunogen MUST first be recognized as foreign by the body
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13. Adaptive vs Innate Immunity

14. Primary vs Secondary Responses

15. Humoral Immunity

16. Antibodies Distinguish Between
Diseases
measles & mumps
Macromolecules
proteins, complex carbohydrates
Molecules
amino acids, sugars
Submolecular Structures
D& L isomers; ortho, meta, para positions
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17. B cell blasts

18. B Cell Transformation

19. Clonal Selection: B cells

20. Immunglobulin on B cells

21. Plasma cell function

22. Antibody: a Flexible mediator

23. Plasma cell: function

24. Complement functions

25. Cell Mediated Immunity

26. T cell blasts

27. T cell blasts: structure

28. T cells

29. Cell mediated clonal selection

30. T cell transformation

31. T cells ANAE stain

32. Role of Macrophages

33. Monocyte

34. Monocyte structure

35. Macrophage Activation products

36. Macrophages & T cells

37. T cells interacting with Macrophage

38. Macrophage mediatiors: CD14 receptor

39. Macrophage mediators: CD14 & LPS receptors

40. Endotoxin induction of Macrophage mediators: direct induction

41. Oponsization: mechanisms

42. Regulation of Immunity

43. Range of immune responses

44. Antigen Processing

45. Cellular interactions during the humoral response

46. A Complete Immune Response
Lymphocytes
B cells
T cells
Macrophages
critical accessory cells
Complement
combines with antibody to enhance destruction
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47. White Blood Cells

48. Adverse effects of Immunity

49. The End

50. Acquired Immunity: Questions
How does clonal selection contribute to memory in the immune response?
Name three feature of a secondary immune response that make it different from a primary immune response.

51. Questions(1)
Interleukin 2 is a nonspecific growth factor that stimulates the growth of TH cells during the immune response. In view of this nonspecificity of IL-2, what mechanism assures that only TH cells specific for a given antigen proliferate and that all other TH cells do not proliferate

52. Questions (2)
Antigen presenting cells play a role in both humoral and cell mediated immune responses
Name three type af antigen presenting cells
Which class of MHC molecules are expressed on the membrane of antigen presenting cells?
Which lymphocytes interact eith antigen presenting cells?