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Comparative proteomics reveals a systemic vulnerability in the vasculature of patients with abdominal aortic aneurysms  Ian M. Nordon, MD, FRCS, Robert.

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Presentation on theme: "Comparative proteomics reveals a systemic vulnerability in the vasculature of patients with abdominal aortic aneurysms  Ian M. Nordon, MD, FRCS, Robert."— Presentation transcript:

1 Comparative proteomics reveals a systemic vulnerability in the vasculature of patients with abdominal aortic aneurysms  Ian M. Nordon, MD, FRCS, Robert J. Hinchliffe, MD, FRCS, Amir H. Malkawi, MRCS, Grisha Pirianov, PhD, Evelyn Torsney, PhD, Ian M. Loftus, MD, FRCS, Gillian W. Cockerill, PhD, Matt M. Thompson, MD, FRCS  Journal of Vascular Surgery  Volume 54, Issue 4, Pages e6 (October 2011) DOI: /j.jvs Copyright © 2011 Society for Vascular Surgery Terms and Conditions

2 Fig 1 A representative 2-D gel; four spots identified are highlighted.
Journal of Vascular Surgery  , e6DOI: ( /j.jvs ) Copyright © 2011 Society for Vascular Surgery Terms and Conditions

3 Fig 2 Western blot validation of differential protein expression. Error bars demonstrated 95% confidence interval. Journal of Vascular Surgery  , e6DOI: ( /j.jvs ) Copyright © 2011 Society for Vascular Surgery Terms and Conditions

4 Fig 3 Immunohistochemically labeled images demonstrating protein distribution by cell type in IMV specimen. Staining has been performed on snap-frozen IMV samples with acetone fixation (A, Control; B, α-actin (VSMC); C, CD-34 (Endothelial cell); D, cleaved-vimentin; E, prohibitin; F, Annexin A1). Journal of Vascular Surgery  , e6DOI: ( /j.jvs ) Copyright © 2011 Society for Vascular Surgery Terms and Conditions

5 Supplemental Fig 1 ThermoFinnigan LCQ output, vimentin fragment.
Journal of Vascular Surgery  , e6DOI: ( /j.jvs ) Copyright © 2011 Society for Vascular Surgery Terms and Conditions

6 Supplemental Fig 2 Vimentin fragment spectra.
Journal of Vascular Surgery  , e6DOI: ( /j.jvs ) Copyright © 2011 Society for Vascular Surgery Terms and Conditions

7 Supplemental Fig 3 ThermoFinnigan LCQ output, prohibitin.
Journal of Vascular Surgery  , e6DOI: ( /j.jvs ) Copyright © 2011 Society for Vascular Surgery Terms and Conditions

8 Supplemental Fig 4 Prohibitin spectra.
Journal of Vascular Surgery  , e6DOI: ( /j.jvs ) Copyright © 2011 Society for Vascular Surgery Terms and Conditions

9 Supplemental Fig 5 LCQ output, annexin A1.
Journal of Vascular Surgery  , e6DOI: ( /j.jvs ) Copyright © 2011 Society for Vascular Surgery Terms and Conditions

10 Supplemental Fig 6 Annexin A1 spectra.
Journal of Vascular Surgery  , e6DOI: ( /j.jvs ) Copyright © 2011 Society for Vascular Surgery Terms and Conditions

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