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Control theory and homeostasis

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Presentation on theme: "Control theory and homeostasis"— Presentation transcript:

1 Control theory and homeostasis
ZRT1 ZAP1 Control theory and homeostasis Control theory That branch of mathematics and engineering which deals with the design, identification and analysis of systems with a view towards controlling them, i.e., to make them perform specific tasks or to behave in a desired way Homeostasis The ability and tendency of certain systems to maintain a relatively constant internal state in spite of changes in external conditions

2 Human designed control systems

3 Human designed control systems
Cornelis Drebbel 1620

4 satellite attitude control
Human designed control systems satellite attitude control

5 block diagram of a basic feedback control
disturbance control signal reference + controller actuator process input filter output _ sensor block diagram of a basic feedback control

6 Calcium homeostasis

7 increase concentration -> decreased tumbling frequency
Bacterial chemotaxis Run CCW Tumble CW Increasing Chemical Gradient 10µm biased random walk: increase concentration -> decreased tumbling frequency

8 perfect adaptation of tumbling frequency
Tethering Analysis Agonist changes rotational bias Kirby et al (JBC, 1999)

9 intracellular nutrient homeostasis
Zn ZRT2 ZRT1 Zn ZAP1 ZRT1 ZAP1 a simplified model for Zinc homeostasis

10 Searching Pubmed “homeostasis” hits “control theory” 432 “homeostasis” AND “control theory” 27

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