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FNAIT: the fetus pleads guilty!

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Presentation on theme: "FNAIT: the fetus pleads guilty!"— Presentation transcript:

1 FNAIT: the fetus pleads guilty!
by Cécile Kaplan Blood Volume 116(18): November 4, 2010 ©2010 by American Society of Hematology

2 FcRn a key factor in FNIT. (A) Fetal FcRn is required for FNIT
FcRn a key factor in FNIT. (A) Fetal FcRn is required for FNIT. Low platelet counts are observed only in pups expressing fetal FcRn delivered from immunized β3−/−FcRn−/− × β3+/+FcRn−/+. FcRn a key factor in FNIT. (A) Fetal FcRn is required for FNIT. Low platelet counts are observed only in pups expressing fetal FcRn delivered from immunized β3−/−FcRn−/− × β3+/+FcRn−/+. (B) Anti-FcRn monoclonal antibody injection during pregnancy. Low platelet counts are observed only in pups delivered from nontreated immunized female mice. N = platelet counts. (Professional illustration by Paulette Dennis.)‏ Cécile Kaplan Blood 2010;116: ©2010 by American Society of Hematology


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