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Phenotype Annotation at TAIR
Tanya Berardini
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Current Status Phenotypes are associated to organisms (germplasms) and linked to references Curation is mainly done in unstructured full text Pilot study of structured annotation completed PaTO not yet implemented
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papillae:abnormal style:abnormal septum development:incomplete leaf:serrate
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Same challenges as other databases
Large corpus of literature Set number of curators with many diverse responsibilities Different ways of paper prioritization
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Capturing phenotypes from the literature
Single paper, describing single aspect of phenotype Single paper, describing multiple aspects of the organism’s phenotype Multiple papers describing different aspects of the organism’s phenotype Multiple papers, describing the same phenotype First mention? Who gets the attribution? Does it matter? Use a recent review? What is appropriate use of time? Cost-benefit analysis.
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Storing complex annotations in the database
Right now, GO as a model for assocations: 1 association = 1 gene product + 1 CV term How do we deal with multiple ontologies in one association? 1 association = 1 germplasm + 1 anatomy term + 1 PATO term (+ others)
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