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Published byLuis Correa Palma Modified over 6 years ago
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SMAD About Hepatitis C Virus Cell Entry and Liver Disease
Che C. Colpitts Gastroenterology Volume 152, Issue 1, Pages (January 2017) DOI: /j.gastro Copyright © 2017 AGA Institute Terms and Conditions
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Figure 1 Proposed role of I-SMADs during hepatitis C virus (HCV) infection according to Zhang et al.3 I-SMADs, induced by HCV infection, transcriptionally regulate expression of HCV entry factors, including HSPGs and cholesterol uptake receptors. HSPGs, heparan sulfate proteoglycans; SR-BI, scavenger receptor class B type I; LDLR, low density lipoprotein receptor; NF-κB, nuclear factor kappa B; TGF-β, transforming growth factor beta; I-SMADs, inhibitory SMADs. Gastroenterology , 21-23DOI: ( /j.gastro ) Copyright © 2017 AGA Institute Terms and Conditions
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