Presentation is loading. Please wait.

Presentation is loading. Please wait.

Elaine E. Tseng, MD, Malcolm V. Brock, MD, Mary S. Lange, MA, Juan C

Published byAlexandrina Parsons Modified over 6 years ago

Similar presentations

Presentation on theme: "Elaine E. Tseng, MD, Malcolm V. Brock, MD, Mary S. Lange, MA, Juan C"— Presentation transcript:

1 Glutamate Excitotoxicity Mediates Neuronal Apoptosis After Hypothermic Circulatory Arrest 
Elaine E. Tseng, MD, Malcolm V. Brock, MD, Mary S. Lange, MA, Juan C. Troncoso, MD, Mary E. Blue, PhD, Charles J. Lowenstein, MD, Michael V. Johnston, MD, William A. Baumgartner, MD  The Annals of Thoracic Surgery  Volume 89, Issue 2, Pages (February 2010) DOI: /j.athoracsur Copyright © 2010 The Society of Thoracic Surgeons Terms and Conditions

2 Fig 1 Intracerebral glutamate levels (μM) over time with and without MK-801 treatment (A). Intracerebral glycine levels (μM) (B) and intracerebral citrulline levels (μM) (C) over time with and without MK-801 treatment. (■ = HCA; □ = MK-801; * = p < 0.05 compared with baseline; ** = p < 0.05 compared with HCA without MK-801 treatment; CPB = cardiopulmonary bypass; HCA = hypothermic circulatory arrest). The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2010 The Society of Thoracic Surgeons Terms and Conditions

3 Fig 2 Light microscopy of hematoxylin and eosin (H&E) stained sections for a normal dog (A). Apoptosis is seen in a hypothermic circulatory arrest (HCA) treated dog (B). Reduction in apoptosis seen in an MK-801-treated HCA dog shown by light microscopy of H&E stained sections (C). (Original magnification ×100.) The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2010 The Society of Thoracic Surgeons Terms and Conditions

4 Fig 3 Terminal deoxynucleotidyltransferase-mediated deoxyuridine triphosphate biotin nick end-labeling (TUNEL) assay shows no DNA fragmentation in a normal dog (A). The TUNEL demonstrates cells with DNA fragmentation in a hypothermic circulatory arrest (HCA) dog (B). Reduction in cells with DNA fragmentation is seen in an HCA dog treated with MK-801 (C). (Original magnification ×100.) The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2010 The Society of Thoracic Surgeons Terms and Conditions

Download ppt "Elaine E. Tseng, MD, Malcolm V. Brock, MD, Mary S. Lange, MA, Juan C"

Similar presentations

Squamous Cell Carcinoma of the Pericardium Found During Coronary Bypass Surgery of Possible Cutaneous Origin  Alan P. Kypson, MD, Curtis A. Anderson,

Squamous Cell Carcinoma of the Pericardium Found During Coronary Bypass Surgery of Possible Cutaneous Origin  Alan P. Kypson, MD, Curtis A. Anderson,
Bing-Yen Wang, MD, Hsiao-Huang Chang, MD, PhD, I

Bing-Yen Wang, MD, Hsiao-Huang Chang, MD, PhD, I
Serum levels of neuron-specific ubiquitin carboxyl-terminal esterase-L1 predict brain injury in a canine model of hypothermic circulatory arrest  George.

Serum levels of neuron-specific ubiquitin carboxyl-terminal esterase-L1 predict brain injury in a canine model of hypothermic circulatory arrest  George.
Glutamate excitotoxicity: A mechanism of neurologic injury associated with hypothermic circulatory arrest  J.M. Redmond, FRCSI (by invitation), A.M. Gillinov,

Glutamate excitotoxicity: A mechanism of neurologic injury associated with hypothermic circulatory arrest  J.M. Redmond, FRCSI (by invitation), A.M. Gillinov,
Faraz Kerendi, MD, Paul M. Kirshbom, MD, Michael E

Faraz Kerendi, MD, Paul M. Kirshbom, MD, Michael E
Deep Hypothermic circulatory arrest does not impair neurodevelopmental outcome in school-age children after infant cardiac surgery  Stephanie Fuller,

Deep Hypothermic circulatory arrest does not impair neurodevelopmental outcome in school-age children after infant cardiac surgery  Stephanie Fuller,
Rodrigo A. S. Sardenberg, MD, Clovis Pinto, MD, Cynthia A

Rodrigo A. S. Sardenberg, MD, Clovis Pinto, MD, Cynthia A
Collision Tumor of Esophagus: Report of Three Cases

Collision Tumor of Esophagus: Report of Three Cases
Duodenal Reflux Leads to Down Regulation of DNA Mismatch Repair Pathway in an Animal Model of Esophageal Cancer  Pramod Bonde, MD, MS, Daqing Gao, PhD,

Duodenal Reflux Leads to Down Regulation of DNA Mismatch Repair Pathway in an Animal Model of Esophageal Cancer  Pramod Bonde, MD, MS, Daqing Gao, PhD,
Serum levels of neuron-specific ubiquitin carboxyl-terminal esterase-L1 predict brain injury in a canine model of hypothermic circulatory arrest  George.

Serum levels of neuron-specific ubiquitin carboxyl-terminal esterase-L1 predict brain injury in a canine model of hypothermic circulatory arrest  George.
Assessing the impact of cerebral injury after cardiac surgery: will determining the mechanism reduce this injury?  William A Baumgartner, MD, Peter L.

Assessing the impact of cerebral injury after cardiac surgery: will determining the mechanism reduce this injury?  William A Baumgartner, MD, Peter L.
Giant Costal Osteochondroma in a Man With Multiple Exostoses

Giant Costal Osteochondroma in a Man With Multiple Exostoses
Abdominal Aorta Aneurysms in Children: Single-Center Experience of Six Patients  Caisheng Ye, MD, PhD, Henghui Yin, MD, PhD, Ying Lin, MD, PhD, Li Zhou,

Abdominal Aorta Aneurysms in Children: Single-Center Experience of Six Patients  Caisheng Ye, MD, PhD, Henghui Yin, MD, PhD, Ying Lin, MD, PhD, Li Zhou,
Primary Chordoma of the Lung

Primary Chordoma of the Lung
Inhaled nitric oxide attenuates apoptosis in ischemia-reperfusion injury of the rabbit lung  Hideki Yamashita, MD, Shinji Akamine, MD, Yorihisa Sumida,

Inhaled nitric oxide attenuates apoptosis in ischemia-reperfusion injury of the rabbit lung  Hideki Yamashita, MD, Shinji Akamine, MD, Yorihisa Sumida,
Intraoperative Hemoglobin Levels and Transfusion Independently Predict Stroke After Cardiac Operations  Zainab S. Bahrainwala, BS, Maura A. Grega, RN,

Intraoperative Hemoglobin Levels and Transfusion Independently Predict Stroke After Cardiac Operations  Zainab S. Bahrainwala, BS, Maura A. Grega, RN,
Two-Stage End-to-End Reconstruction of Long-Segment Tracheal Defects With a Bioabsorbable Scaffold Grafting Technique in a Canine Model  Hisashi Tsukada,

Two-Stage End-to-End Reconstruction of Long-Segment Tracheal Defects With a Bioabsorbable Scaffold Grafting Technique in a Canine Model  Hisashi Tsukada,
Sarah M. Brant, MD, Michael L. Cobert, PhD, LaShondra M

Sarah M. Brant, MD, Michael L. Cobert, PhD, LaShondra M
Susanne Lison, MD, Michael Spannagl, MD, PhD, Wulf Dietrich, MD, PhD 

Susanne Lison, MD, Michael Spannagl, MD, PhD, Wulf Dietrich, MD, PhD 
Nanotechnology Approaches to Targeting Inflammation and Excitotoxicity in a Canine Model of Hypothermic Circulatory Arrest–Induced Brain Injury  Joshua.

Nanotechnology Approaches to Targeting Inflammation and Excitotoxicity in a Canine Model of Hypothermic Circulatory Arrest–Induced Brain Injury  Joshua.

Similar presentations

Ads by Google