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Alternative Splicing of CD45: The Tip of the Iceberg

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Presentation on theme: "Alternative Splicing of CD45: The Tip of the Iceberg"— Presentation transcript:

1 Alternative Splicing of CD45: The Tip of the Iceberg
Julie Zikherman, Arthur Weiss  Immunity  Volume 29, Issue 6, Pages (December 2008) DOI: /j.immuni Copyright © 2008 Elsevier Inc. Terms and Conditions

2 Figure 1 Alternative Splicing of CD45
Alternative splicing of exons 4, 5, and 6 in naive T cells permits the inclusion of heavily glycosylated segments A, B, and C, respectively, in CD45 cell-surface protein. Variable amounts of high molecular weight isoforms, including RABC, RAB, RBC, and RB are detected on the surface of naive T cells. Upon differentiation to memory T cells, upregulation of hnRNPLL inhibits splicing and inclusion of exons 4, 5, and 6, generating predominantly the short isoform CD45RO. Immunity  , DOI: ( /j.immuni ) Copyright © 2008 Elsevier Inc. Terms and Conditions

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