1. Moving toward endotypes in atopic dermatitis: Identification of patient clusters based on serum biomarker analysis 
Judith L. Thijs, MD, Ian Strickland, PhD, Carla A.F.M. Bruijnzeel-Koomen, MD, PhD, Stefan Nierkens, PhD, Barbara Giovannone, PhD, Eszter Csomor, PhD, Bret R. Sellman, PhD, Tomas Mustelin, MD, PhD, Matthew A. Sleeman, PhD, Marjolein S. de Bruin-Weller, MD, PhD, Athula Herath, PhD, Julia Drylewicz, PhD, Richard D. May, PhD, DirkJan Hijnen, MD, PhD 
Journal of Allergy and Clinical Immunology 
Volume 140, Issue 3, Pages (September 2017)
DOI: /j.jaci
Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2. Fig 1
PCA and cluster analysis of patients with AD. A, PCA of Box-Cox normalized serum data reveals the presence of 4 likely clusters. Blue ovals are illustrative annotations representing 4 likely clusters. B, Eight PCs describe 50% of the variance, and 57 PCs describe 90% of the variance in the Box-Cox normalized serum data set. C, Generation of 4 clusters of patients with AD by using unsupervised k-means clustering of the 57 most important PCs into 4 clusters using a predefined seed value. Clinical characteristics (not included in the cluster analysis) were analyzed between the 4 clusters (Table II), and averages of serum analytes per cluster were calculated and tabulated to characterize the clusters (see Tables E2 and E3). This figure shows characterization of the 4 AD clusters. MIG, Monokine-induced by interferon-γ; TWEAK, TNF-like weak inducer of apoptosis.
Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci )
Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions