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Ketamine* Journal of Pain and Symptom Management

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1 Ketamine* Journal of Pain and Symptom Management
Rachel Quibell, FRCP, Marie Fallon, MD, FRCP, Mary Mihalyo, BS, PharmD, BCPS, Robert Twycross, DM, FRCP, Andrew Wilcock, DM, FRCP  Journal of Pain and Symptom Management  Volume 50, Issue 2, Pages (August 2015) DOI: /j.jpainsymman Copyright © Terms and Conditions

2 Fig. 1 Diagram of the NMDA (excitatory) receptor-channel complex. The channel is blocked by magnesium (Mg2+) when the membrane potential is at its resting level (voltage-dependent block) and by drugs which act at the phencyclidine (PCP) binding site in the glutamate-activated channel, e.g. dextromethorphan, ketamine, methadone (use-dependent block).4 Journal of Pain and Symptom Management  , DOI: ( /j.jpainsymman ) Copyright © Terms and Conditions


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