1. Distribution of mutations in different groups of genes, in cancer with extreme ML values.
Distribution of mutations in different groups of genes, in cancer with extreme ML values. (A) AML patients (n = 163). The number of N minus the number of S mutations (left y axis) indicates the excess of N mutations in each group of genes separately (color). The number of S mutations in the entire proteome is superimposed (black). Patients are ordered by the dN/dS acting on the proteome (right y axis). (B) Melanoma patients (n = 287). In AML, for more than half of the patients, dN/dS > 1, and cancer genes harbor a substantial fraction of the N mutations. In melanoma, dN/dS is below unity in the vast majority of patients, and dN/dS sharply drops with the number of mutations in the proteome, which, coupled with β < 0, indicates mutation meltdown (Muller’s ratchet).
Erez Persi et al. PNAS 2018;115:47:E11101-E11110
©2018 by National Academy of Sciences