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Molecular Genetics of Demyelination: New Wrinkles on an Old Membrane

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Presentation on theme: "Molecular Genetics of Demyelination: New Wrinkles on an Old Membrane"— Presentation transcript:

1 Molecular Genetics of Demyelination: New Wrinkles on an Old Membrane
Steven S. Scherer  Neuron  Volume 18, Issue 1, Pages (January 1997) DOI: /S (01)

2 Figure 1 Ultrastructure of a Myelinated Fiber From a 5-Day-Old Mouse Sciatic Nerve (A) An axon (a), its myelin sheath (m), Schwann cell nucleus (n), and basal lamina (arrowheads). Scale bar, 0.5 mm. (B) Compact myelin is composed of alternating major dense lines (arrows) and interperiod lines; the distance between the major dense lines is 15 nm. Neuron  , 13-16DOI: ( /S (01) )

3 Figure 2 Localization of Myelin Components in the Mammalian CNS and PNS Myelin Sheaths Noncompact myelin is found at the paranodes in the mammalian CNS, but it lacks some of the molecular specializations found in noncompact myelin of the PNS myelin, such as MAG and E-cadherin. Although MAG is illustrated as interacting homophilically, this is unproven. Neuron  , 13-16DOI: ( /S (01) )


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