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Females Battle to Suppress Their Inner Male

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1 Females Battle to Suppress Their Inner Male
Andrew Sinclair, Craig Smith  Cell  Volume 139, Issue 6, Pages (December 2009) DOI: /j.cell Copyright © 2009 Elsevier Inc. Terms and Conditions

2 Figure 1 Gonad Differentiation in Mammals
Shown is the effect on the gonads of deleting Foxl2 in adult mice. The undifferentiated embryonic gonad comprises supporting and steroidogenic cell precursors, together with primordial germ cells. In the presence of Sry and Sox9, differentiation into testis occurs. In the presence of Foxl2 and R-spondin1/Wnt4 acting via β-catenin, the embryonic gonad differentiates into ovary. When Foxl2 is genetically ablated in adult female mice (XX), the ovary transdifferentiates into testis, with granulosa and theca cells becoming Sertoli and Leydig cells, respectively, and the germ cells are lost. Cell  , DOI: ( /j.cell ) Copyright © 2009 Elsevier Inc. Terms and Conditions

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