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Making Ends Meet: Myeloid Cells Catalyze Blood Vessel Repair in the Brain
Aleksandra Deczkowska, Michal Schwartz Immunity Volume 44, Issue 5, Pages (May 2016) DOI: /j.immuni Copyright © 2016 Elsevier Inc. Terms and Conditions
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Figure 1 Myeloid Cells’ Roles in Acute CNS Injury
Upon rupture of a blood vessel in the brain, the tissue immediately shows signs of stress, e.g., microglia activation and neuronal death. Under these conditions, myeloid cells (both microglia and infiltrating, monocyte-derived macrophages) fulfill a range of protective roles, including phagocytosis of cellular debris, release of neuroprotective factors, and, as now reported by Liu et al. (2016), directly supporting re-ligation of ruptured blood vessels by adhesion and mechanical traction. Immunity , DOI: ( /j.immuni ) Copyright © 2016 Elsevier Inc. Terms and Conditions
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