1. Registry-based randomised controlled trials – the future for clinical trials?
Session Moderator: Marion Campbell
Professor of Health Services Research
@MarionKCampbell

2. Our challenge Cost of trials escalating
Trials seen to be burdensome to run; require stand alone infrastructure and lots of data collection
The challenge…
How can we evaluate rigorously BUT efficiently?
Potential solution…
Registry-based randomised controlled trials?

3. What is a registry?
“A patient registry is an organized system that uses observational study methods to collect uniform data (clinical and other) to evaluate specified outcomes for a population defined by a particular disease, condition, or exposure, and that serves a predetermined scientific, clinical, or policy purpose(s)”…AHRQ

4. What are Registry based trials?
Trials that are seamlessly nested onto the registry infrastructure
Use the registry as a platform for data collection, follow up (and ideally) randomisation
… the next “disruptive technology in clinical trials”?

5. Content of session Overview of RRCTs?
Updates on international projects researching RRCTs
Information on the practical liaison of trials with registries
Using registries to track innovation for evaluation
Discussion

6. Speakers Prof Lehana Thabane, McMaster University, Canada
Dr Ted Lystig, Medtronic & CTTI initiative, US
Prof David Beard, University of Oxford, UK
Prof Jane Blazeby, University of Bristol, UK
Open discussion