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Hereditary Nonpolyposis Colorectal Cancer in 95 Families: Differences and Similarities between Mutation-Positive and Mutation-Negative Kindreds  Rodney.

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Presentation on theme: "Hereditary Nonpolyposis Colorectal Cancer in 95 Families: Differences and Similarities between Mutation-Positive and Mutation-Negative Kindreds  Rodney."— Presentation transcript:

1 Hereditary Nonpolyposis Colorectal Cancer in 95 Families: Differences and Similarities between Mutation-Positive and Mutation-Negative Kindreds  Rodney J. Scott, Mary McPhillips, Cliff J. Meldrum, Patrick E. Fitzgerald, Kirsten Adams, Allan D. Spigelman, Desiree du Sart, Kathy Tucker, Judy Kirk  The American Journal of Human Genetics  Volume 68, Issue 1, Pages (January 2001) DOI: /316942 Copyright © 2001 The American Society of Human Genetics Terms and Conditions

2 Figure 1 Complex DNA sequence changes identified in hMSH2
The American Journal of Human Genetics  , DOI: ( /316942) Copyright © 2001 The American Society of Human Genetics Terms and Conditions

3 Figure 2 Age at diagnosis in 292 patients with familial colorectal carcinoma, according to mutation status. One to six affected mutation-positive family members were included in this analysis, and only hMSH2 and hMLH1 causative mutations were included. The American Journal of Human Genetics  , DOI: ( /316942) Copyright © 2001 The American Society of Human Genetics Terms and Conditions

4 Figure 3 Relative percentage of malignancies within the three groups of families with HNPCC. The tumor spectrum was determined on the basis of 559 patients with cancer, all of whom were from families with a clustering of CRC. The American Journal of Human Genetics  , DOI: ( /316942) Copyright © 2001 The American Society of Human Genetics Terms and Conditions


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