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Published byἩσίοδος Κακριδής Modified over 6 years ago
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Transcription factor SOHLH1 potentially associated with primary ovarian insufficiency
Shidou Zhao, Ph.D., Guangyu Li, M.Sc., Raymond Dalgleish, Ph.D., Svetlana Vujovic, Ph.D., Xue Jiao, M.D., Jin Li, Ph.D., Joe Leigh Simpson, M.D., Yingying Qin, Ph.D., Maja Ivanisevic, Ph.D., Miomira Ivovic, Ph.D., Milina Tancic, Ph.D., Farook Al-Azzawi, Ph.D., Zi- Jiang Chen, Ph.D. Fertility and Sterility Volume 103, Issue 2, Pages e5 (February 2015) DOI: /j.fertnstert Copyright © 2015 American Society for Reproductive Medicine Terms and Conditions
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Figure 1 Identification and functional analysis of novel variants in SOHLH1 gene in Chinese POI patients. (A) Schematic diagram of the SOHLH1 gene, showing three novel variants in exons of the SOHLH1 gene and one in the 3′ untranslated region (UTR). The exons correspond to human sequence NM_ (GenBank RefSeq). The bHLH domain is encoded in exons 2 and 3. (B) SOHLH1 C-terminal domain alignment among different species. (C) Part of the SOHLH1 3′ UTR alignment among different species. (D) Prediction of the miRNA binding with the SOHLH1 3′ UTR in the presence of the variant sequence. Arrows in B and C indicate the novel variants, and asterisks (*) indicate the amino acid and nucleotide residues that are conserved in all the species. Fertility and Sterility , e5DOI: ( /j.fertnstert ) Copyright © 2015 American Society for Reproductive Medicine Terms and Conditions
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