1. The Vicious Cycle of Chronic Migraine How Can the Physician Help?

3. This program will include a discussion of data that were presented in abstract form. These data should be considered preliminary until published in a peer-reviewed journal.

4. Program Overview

5. Global Burden of Migraine

6. Loss of Work Time in Patient With Migraine: AMPP Study for 2006

7. Patient Case History: Sylvia

8. Patient Case History: Sylvia (cont)

9. Patient Case: Sylvia's Current Condition

10. How Common Is Sylvia's Case?

11. Progression to Chronic Migraine: Sylvia's Case

12. Risk Factors for Migraine Chronification

13. Current Evidence-Based Migraine Prevention Treatments: EFNS Guidelines

14. Complementary Therapies for Migraine

15. Treatment Choice Based on the Individual

16. Reasons Reported by Patients for Discontinuation of Preventive Migraine Medication

17. Revisiting Sylvia's Case

18. Clinical Approach 1 for Sylvia

19. Clinical Approach 2 for Sylvia

20. Clinical Approach 3 for Sylvia

21. What Do the Guidelines Recommend?

22. Current Preventive Therapies for Migraine: Unmet Needs

23. mAbs Targeting the CGRP Pathway for Migraine Prevention

24. Safety of Anti-CGRP mAbs: Similar to Placebo

25. Small Molecule CGRP Receptor Blockers: Gepants

26. Anti-CGRP mAbs: 50% Responder Rates in Chronic Migraine

27. Reduction in Monthly Acute Migraine-Specific Medication Treatment Days in Chronic Migraine: Erenumab and Fremanezumab

28. Anti-CGRP mAb CV Safety Findings

29. Site of Action of CGRP Targeted Drugs: The Trigeminal Ganglion and the BBB

30. Future Treatment Options for Sylvia: Clinical Opinions

31. Abbreviations

32. Abbreviations (cont)