1. Treatment of Generalized Tonic-Clonic Seizures in the Modern Era

3. This program will include a discussion of off-label treatment and investigational agents not approved by the FDA for use in the US.

4. 2017 ILAE Epilepsy Nomenclature

5. Most Common IGE Syndromes

6. DRE at UK Epilepsy Referral Clinics

7. Case 1

8. Case 1: Care by a General Neurologist

9. Case 1: Testing, Results, and Diagnosis

10. Importance of Referral

11. Apparent Drug Resistance in IGE

12. Treatment Goals in IGE

13. Expert Opinion Survey: Design

14. Expert Opinion Survey: Treatment of IGE With GTCS First Monotherapy

15. Expert Opinion Survey: Treatment of IGE With GTCS First Monotherapy (cont)

16. Expert Opinion Survey: Initial AED Selection*

17. Expert Review: AEDs of Choice

18. Perampanel: FDA Approved for GTCS

19. Other Drugs Used for the Treatment of GTCS

20. Case 2: General History

21. Case 2: Seizure History

22. Case 2: Findings and Diagnosis

23. Case 2: Treatment Considerations

24. Case 2: Selecting AEDs

25. Case 2: Treatment Options First Monotherapy

26. Case 2: Treatment Options First Monotherapy (cont)

27. Case 2: Treatment Options First Monotherapy (cont)

28. Case 2: Treatment Options First Monotherapy (cont)

29. Case 2: Treatment Options First Monotherapy (cont)

30. Case 2: Treatment Selection

31. North American AED Pregnancy Registry

32. Basis of Uncontrolled Seizures With First-Line AED

33. Case 3: History

34. Case 3: Selecting AED in DRE

35. Treating DRE

36. Conclusions

37. Abbreviations

38. Abbreviations