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Evaluation of early administration of simvastatin in the prevention and treatment of delirium in critically ill patients undergoing mechanical ventilation.

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Presentation on theme: "Evaluation of early administration of simvastatin in the prevention and treatment of delirium in critically ill patients undergoing mechanical ventilation."— Presentation transcript:

1 Evaluation of early administration of simvastatin in the prevention and treatment of delirium in critically ill patients undergoing mechanical ventilation (MoDUS): a randomised, double-blind, placebo-controlled trial  Dr Valerie J Page, MBBCh, Annalisa Casarin, MD, Prof E Wesley Ely, MD, Xiao Bei Zhao, BSc, Cliona McDowell, MSc, Lynn Murphy, BSc, Prof Daniel F McAuley, MD  The Lancet Respiratory Medicine  Volume 5, Issue 9, Pages (September 2017) DOI: /S (17) Copyright © 2017 Elsevier Ltd Terms and Conditions

2 Figure 1 Trial design *Some categories are double counted to allow for patients who met multiple criteria (appendix p 11). IMP=investigational medicinal product. The Lancet Respiratory Medicine 2017 5, DOI: ( /S (17) ) Copyright © 2017 Elsevier Ltd Terms and Conditions

3 Figure 2 Kaplan-Meier plot for all cause mortality at 6 months
HR=hazard ratio. The Lancet Respiratory Medicine 2017 5, DOI: ( /S (17) ) Copyright © 2017 Elsevier Ltd Terms and Conditions

4 Figure 3 Kaplan-Meier plot for time to discharge from hospital
HR=hazard ratio. The Lancet Respiratory Medicine 2017 5, DOI: ( /S (17) ) Copyright © 2017 Elsevier Ltd Terms and Conditions


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