1. Clayton Wiley, M.D./PhD

2. Question 1
A 5-year-old girl presents with a ~6 week history of early morning headaches. Describe the findings in her MRI scan.

3. T1

4. T1 plus contrast

5. T1 plus contrast

6. Question 2
What is your major differential diagnosis for posterior fossa tumors in children?

7. Answer
Ependymoma
Pilocytic astrocytoma
Medulloblastoma

8. Question 3
An intraoperative consultation was requested and performed via telepathology. Describe the findings in the intraoperative smear preparation on the following representative snapshots obtained via the telepathology system.

11. Question 4
What is your intraoperative diagnosis?

12. Answer
Medulloblastoma

13. Question 5
A resection of the mass was performed. Describe the findings in the following representative permanent H&E slide. Click here to view slide.

14. Question 8
Describe the findings in the following immunohistochemical slides for synaptophysin and Ki-67. Click here to view slide