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How IRE1 Reacts to ER Stress

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Presentation on theme: "How IRE1 Reacts to ER Stress"— Presentation transcript:

1 How IRE1 Reacts to ER Stress
David Ron, Stevan R. Hubbard  Cell  Volume 132, Issue 1, Pages (January 2008) DOI: /j.cell Copyright © 2008 Elsevier Inc. Terms and Conditions

2 Figure 1 Structure of the Cytosolic Domain of Yeast IRE1
The two protomers of the IRE1 dimer observed in the crystal structure (two-fold axis is vertical) are colored purple and green, with the kinase domains in a darker shade and the endoribonuclease (KEN) domains in a lighter shade. The positions of the kinase and (putative) endoribonuclease active sites are shown by arrows, and the bound ADP molecules are colored blue. Cell  , 24-26DOI: ( /j.cell ) Copyright © 2008 Elsevier Inc. Terms and Conditions

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