1. Updates in Pyruvate Kinase Deficiency

3. Program Goals

4. Deficient Glycolytic Pathway and Its Effects on RBC Viability

5. PKD Prevalence

6. PKD Epidemiology

7. Signs of PKD Infants

8. Signs of PKD Children and Adults

9. Factors Suggestive of PKD

10. Testing to Confirm or Rule out Diagnosis of PKD

11. Symptoms and Potential Complications of PKD

12. Splenectomy in PKD

13. Iron Overload

14. Other Complications With PKD

15. Current Management Options

16. Current Management Options (cont)

17. New and Emerging Therapies

18. AG-348 Healthy Volunteer Study

20. Key Takeaway Points

21. Abbreviations

22. References

23. References (cont)

24. References (cont)

25. References (cont)