1. Characteristics of advanced fibrosis in usual interstitial pneumonia of idiopathic pulmonary fibrosis include a subpleural distribution of fibrosis (A, 20×, H&E), relative frequency of fibroblast foci (arrows) and relative absence of any significant inflammatory cell infiltrate (B, 400×, H&E), smooth muscle proliferation in the subpleural scars (asterisk) (C, 40×, H&E), and the frequent occurrence of microscopic honeycomb remodelling (D, 20×, H&E).
Characteristics of advanced fibrosis in usual interstitial pneumonia of idiopathic pulmonary fibrosis include a subpleural distribution of fibrosis (A, 20×, H&E), relative frequency of fibroblast foci (arrows) and relative absence of any significant inflammatory cell infiltrate (B, 400×, H&E), smooth muscle proliferation in the subpleural scars (asterisk) (C, 40×, H&E), and the frequent occurrence of microscopic honeycomb remodelling (D, 20×, H&E).
Maxwell Smith et al. J Clin Pathol 2013;66:
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