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Leukocyte Circulation and Migration into Tissues

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Presentation on theme: "Leukocyte Circulation and Migration into Tissues"— Presentation transcript:

1 Leukocyte Circulation and Migration into Tissues
Chapter 3 Leukocyte Circulation and Migration into Tissues

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6 CHEMOKINES AND CHEMOKINE RECEPTORS

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8 Biologic Actions of Chemokines
Chemokines are essential for the recruitment of circulating leukocytes from blood vessels into extravascular Extravascular chemokines stimulate movement of leukocytes and their migration toward the chemical gradient of the secreted protein, a process called chemokinesis Chemokines are involved in the development of lymphoid organs, and they regulate the traffic of lymphocytes and other leukocytes through peripheral lymphoid Chemokines are required for the migration of dendritic cells from sites of infection into draining lymph nodes

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10 MIGRATION AND RECIRCULATION OF T LYMPHOCYTES

11 High Endothelial Venules (HEVs)

12 Migration of naive and effector T lymphocytes

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