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Red: stable co-clustering Blue: no co-clustering

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Presentation on theme: "Red: stable co-clustering Blue: no co-clustering"— Presentation transcript:

1 Red: stable co-clustering Blue: no co-clustering
Supplementary Figure 1 Red: stable co-clustering Blue: no co-clustering 2-cluster 3-cluster Results of NMF in 74 samples from the WG dataset These plots show how often each pair of samples (74x74 pairings) were in the same cluster during 20 iterations of NMF. Dark red means the samples were always in the same cluster and dark blue means they never were. There is support for 2, 3, and 4 stable cluster assignments by NMF. K5 and K6 are unstable. 4-cluster 5-cluster

2 Supplementary Figure 2

3 Supplementary Figure 3

4 Supplementary Figure 4 P=0.16 EGFR mutation

5 Supplementary Figure 5

6 Supplementary Figure 6 EGFR mutation KRAS mutation

7 26 10 16 14 5 7 17 104 n=199 DUSP4 deletion p16 deletion EGFR mutation
Supplementary Figure 7 p=0.0001 DUSP4 deletion p16 deletion 26 10 16 14 5 7 p= p=0.007 17 104 EGFR mutation n=199

8 Wild type EGFR EGFR del19 EGFR L858R
Supplementary Figure 8 6E-16 Wild type EGFR EGFR del19 EGFR L858R 5E-16 4E-16 DUSP4 mRNA conc (uM) 3E-16 2E-16 1E-16 WT - No EGF WT - 2 hrs WT - 4 hrs WT - 30 min WT - 1 hr WT - 6 hrs del19 - No EGF del min del hrs del hrs del hrs L858R - No EGF del hr L858R - 30 min L858R - 2 hrs L858R - 4 hrs L858R - 1 hr L858R - 6 hrs

9 Supplementary Figure 9 A B GFP DUSP4-GFP H358 H1650 H1650 DUSP4 Vector
70KD DUSP4-GFP 27KD GFP ACTIN H358 H1650 H1650

10 Supplementary Figure 10 H1650 cells 24hrs after electroporation H1650 cells after one week selection GFP DUSP4-GFP


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