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Management of Glioblastoma

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Presentation on theme: "Management of Glioblastoma"— Presentation transcript:

1 Management of Glioblastoma

2

3

4 Standard of Care for Newly Diagnosed GBM

5 Standard of Care for Newly Diagnosed GBM (cont.)

6 Bevacizumab Not Supported for Newly-Diagnosed GBM

7 Bevacizumab + Lomustine

8 Second-Line Therapy for GBM

9 Newly-Diagnosed GBM

10 Addition of Bevacizumab to First-Line Radiotherapy + Temozolomide Retrospective Analysis of the AVAglio Trial

11 Tumor Treating Fields

12 ABT-414 Phase 1 Trial of EGFR-Targeted Monoclonal Antibody Drug Conjugate

13 ABT-414 Adverse Events

14 Nivolumab: PD-1 Antibody Mechanism of Action

15 Nivolumab Checkmate-143: Phase 1 Trial

16 Pembrolizumab: PD-1 Antibody KEYNOTE-28 (Phase 2 Trial)

17 PD-L1 Antibody Ongoing Phase 2 Study of Durvalumab

18 Case Reports and PD-L1 as a Biomarker

19 Rindopepimut: EGFRvIII-Targeted Vaccine

20 TAVAREC: Temozolomide ± Bevacizumab in Grade 2/3 Glioma

21 CATNON Phase 3 Trial: Concurrent and Adjuvant Temozolomide in Anaplastic Grade 3 Glioma

22 IDH Mutations: Key Therapeutic Targets

23 Concluding Remarks

24 Abbreviations

25 Abbreviations (cont)


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