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A [Cu]rious Ribosomal Profiling Pattern Leads to the Discovery of Ribosomal Frameshifting in the Synthesis of a Copper Chaperone  John F. Atkins, Gary.

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Presentation on theme: "A [Cu]rious Ribosomal Profiling Pattern Leads to the Discovery of Ribosomal Frameshifting in the Synthesis of a Copper Chaperone  John F. Atkins, Gary."— Presentation transcript:

1 A [Cu]rious Ribosomal Profiling Pattern Leads to the Discovery of Ribosomal Frameshifting in the Synthesis of a Copper Chaperone  John F. Atkins, Gary Loughran, Pavel V. Baranov  Molecular Cell  Volume 65, Issue 2, Pages (January 2017) DOI: /j.molcel Copyright © 2017 Elsevier Inc. Terms and Conditions

2 Figure 1 Components of Copper Homeostasis in E. coli
Alignment in GWIPS-viz (Michel et al., 2014) of ribosome protected (RiboSeq: blue) and naked RNA (RNASeq: light blue) fragments along part of the E. coli genome encoding the copper efflux pump CopA. The dramatic decrease in the number of ribosome footprints occurs as a result of programmed ribosomal frameshifting into the −1 reading frame where a stop codon is immediately encountered, thus synthesizing the CopZ protein. Molecular Cell  , DOI: ( /j.molcel ) Copyright © 2017 Elsevier Inc. Terms and Conditions

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