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Nucleosomes and Cisplatin

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1 Nucleosomes and Cisplatin
Vincent Murray  Chemistry & Biology  Volume 17, Issue 12, Pages (December 2010) DOI: /j.chembiol Copyright © 2010 Elsevier Ltd Terms and Conditions

2 Figure 1 Two Procedures for Investigation of the Interaction of Cisplatin with Nucleosomal DNA (A) Cisplatin adducts are formed on a defined DNA sequence, an octamer of histones is added, and a Pt-nucleosome complex is produced. (B) A nucleosome is constructed on a defined DNA sequence, the nucleosome is treated with cisplatin, and the Pt-DNA adducts are analyzed. Chemistry & Biology  , DOI: ( /j.chembiol ) Copyright © 2010 Elsevier Ltd Terms and Conditions

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