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Total Synthesis of Cribrostatin IV and ET-743

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Presentation on theme: "Total Synthesis of Cribrostatin IV and ET-743"— Presentation transcript:

1 Total Synthesis of Cribrostatin IV and ET-743
Literature Meeting Presented by Nancy Labbé-Giguère January 30th, 2006 Danishefvsky, S. et al, J. Am. Chem. Soc. 2005, 127,

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18 D-amino acid

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20 What is the structure of Fremy Salt?
Mechanism of the reaction?

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22 X Substrate unstable to mildly basic conditions.
- Ketone was attacked by nucleophile. Cleavage of the β-dicarbonyl bond was observed.

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24 PIFA ?? For the selective oxidation of ring A, see: Conant, J. B.; Fieser, L. F. J. Am. Chem. Soc. 1924, 46, 1858.

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