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Metastasis gets site specific

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Presentation on theme: "Metastasis gets site specific"— Presentation transcript:

1 Metastasis gets site specific
Christine E. Horak, Patricia S. Steeg  Cancer Cell  Volume 8, Issue 2, Pages (August 2005) DOI: /j.ccr Copyright © 2005 Elsevier Inc. Terms and Conditions

2 Figure 1 Schematic of breast tumor cell progression as it pertains to site-specific metastasis and colonization to bone and lung tissue Normal mammary epithelium undergoes oncogenic transformation, and metastasis to distant organs is characterized by the expression of distinct sets of genes. The Venn diagram represents genes that contribute to homing and metastatic colonization, with genes involved in bone-specific metastasis and lung-specific metastasis and genes that are shared between the two common metastatic sites indicated. Cancer Cell 2005 8, 93-95DOI: ( /j.ccr ) Copyright © 2005 Elsevier Inc. Terms and Conditions


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