1. Headache Group @ King’s

2. MIGRAINE: Is it just bad timing?
Circadian Mechanisms in Migraine
Lauren Strother, PhD Candidate
Migraine Trust International Symposium
9 September, 2018

3. Migraine and Circadian Rhythms
Migraine Susceptibility
Shift Work
Jet Lag
Migraine Attack

4. Migraine and Circadian Rhythms
Migraine Attack Onset
Chronotypes
Shift Work
Alstadhaug et al. (2008) Headache. 48(1):
van Oosterhout et al. (2018) Cephelagia. 38(4):

5. Migraine and Circadian Rhythms
FAMILIAL ADVANCE SLEEP PHASE SYNDROME (FASPS)
Shift Work

6. FASPS Mice: Migraine Readouts
Migraine Aura
N=12/12; P<0.001 *
n = 12/12; p < 0.05
Strother et al. (2017) Cephalagia. 37(IS) p202
Control

7. FASPS Mice: Migraine Readouts
Migraine Allodynia *
n=12
p < 0.01
Baseline
2hr NTG
Control
FASPS
Control
FASPS
Migraine Trigger: Nitroglycerin (NTG)
Strother et al. Unpublished

8. Circadian Variation in Pain Perception
Diurnal Variation in WT
n=24
Strother et al. Unpublished

9. Chronic Jet Lag Diurnal Variation in WT * * Lights On: 7:00h
Lights Off: 19:00h * *
n=12
n=12
Controls
Jet Lag
Controls
Jet Lag
Strother et al. Unpublished
Strother et al. Unpublished

10. Migraine Susceptibility
Hope for the Future
Migraine Susceptibility
Shift Work
Jet Lag

11. Dr Philip Holland
Professor Peter Goadsby
Dr Marta Vila Pueyo
Jao Saengjaroentham
Paula Sureda Gibert
Dr Olivier Brock