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Metabolic Diseases Lesson 2.3
Glucose homeostasis in the blood – Part 2
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NADH & FADH2 for the electron transport chain
Do Now:homeostasis Which of these pathways are activated when blood glucose is high? When it is low? Glycogen Glucose Fatty Acids Amino Acids Triglycerides Protein Citric Acid Cycle NADH & FADH2 for the electron transport chain
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Do Now: Low Blood Glucose
Glycogen Protein Triglycerides Glucose Citric Acid Cycle Amino Acids Fatty Acids NADH & FADH2 for the electron transport chain
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Do Now: High Blood Glucose
Glycogen Triglycerides Protein Glucose Citric Acid Cycle Amino Acids Fatty Acids NADH & FADH2 for the electron transport chain
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What organs are involved in energy metabolism?
Where do the metabolic pathways happen?
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The liver is the MASTER REGULATOR: It stores and un-stores energy, and makes new glucose
Adipose stores fat Glycogen Protein
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Storing extra glucose –
It starts in the liver Glucose Acetyl CoA Glycogen Citric Acid Cycle
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Storing extra glucose – The muscle stores glucose to use later
Glycogen Glucose Glucose Protein Acetyl CoA Glycogen Citric Acid Cycle Amino acids
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Storing extra glucose – Extra glucose is stored as fat
Adipose stores fat Glucose Triglyceride Acetyl CoA Lipogenesis Makes fat Citric Acid Cycle
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Putting it all together
Storing Energy Glycogen Adipose stores fat Glucose Glucose Triglyceride Protein Acetyl CoA Lipogenesis Makes fat Glycogen Citric Acid Cycle Amino acids
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The liver is the MASTER REGULATOR: it un-stores energy and makes new glucose
Amino Acids Glucose Glycogen Fatty Acids Adipose stores fat The liver is the only organ that can release glucose into the blood!
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Un-storing glucose: Glycogen is used first!
Citric Acid Cycle Acetyl CoA Glucose Glycogen Glucose Remember, glucose stored in the muscles can only be used in that muscle!
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When glycogen is running low: 1
When glycogen is running low: 1. Amino acids are used for gluconeogenesis & energy Acetyl CoA Glucose Amino acids Glycogen Glucose Protein Citric Acid Cycle Gluconeogenesis
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When glycogen is running low: 2. Lipolysis creates Acetyl CoA
Adipose stores fat Lipolysis breaks down fat Acetyl CoA Glucose Amino acids Glycogen Triglyceride Glucose Protein Citric Acid Cycle
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After several days of fasting we rely solely on the adipose!
stores fat Lipolysis breaks down fat Ketones Triglyceride Citric Acid Cycle
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Putting it all together Un-Storing Energy (S1 – 24 hrs, S2 – several days/when A.A. run out, S3 – Fatty acids convert to ketones – work like glucose) Adipose stores fat *Lipolysis breaks down fat Acetyl CoA Glucose Amino acids Stage 1 - Glycogen Triglyceride Glucose Protein Citric Acid Cycle Stage 2 *Gluconeogenesis Stage 2 * = must run together
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Worksheet 2.4 Directions - Work in small groups to draw arrows into the figures on the first page. Describe the processes of storing energy and un-storing energy. If there is time have students work on the first page of the worksheet. If you run out of time assign this as homework.
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Glucose Wrap Up: Storing Energy Glycogen Protein Glycogen Amino acids
Adipose stores fat Glucose Glucose Triglyceride Protein Acetyl CoA Lipogenesis Makes fat Glycogen Citric Acid Cycle Amino acids
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Wrap Up: Un-Storing Energy
Adipose stores fat Lipolysis breaks down fat Acetyl CoA Glucose Amino acids Glycogen Triglyceride Glucose Protein Citric Acid Cycle
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Complete/revise your work on the worksheet.
Homework Complete/revise your work on the worksheet.
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