1. Replication and Pathology
Chikungunya Virus
Sarah Chen | BIOL402 Infectious Disease in the Developing World
The Virus
Replication and Pathology
Viperin restricts chikungunya virus replication and pathology. Teng et al 2012
Alphavirus
Structural proteins & nonstructural proteins
Figure 2.
Viperin controls CHIKV infection in mice in vitro.
Figure 1.
Overexpression of viperin controls CHIKV replication.
The Disease
Epidemiology
References
Chikunguya virus and the global spread of mosquito-borne disease. Weaver and Lecuit 2015
Center for Disease Control and Prevention. Chikungunya Virus [Internet]. Available from:
Simizu B, Yamamoto K, Ogata T, Hashimoto K Structural proteins of Chikungunya virus Journal of Virology. Journal of Virology 51:254–258.
Teng TS, Foo S, Chin K, Ng L, Teo T, Lulla A, Yeo NK, Koh EG, Chow A, Leo Y, et al Viperin restricts chikungunya virus replication and pathology. Journal of Clinical Investigation. Journal of Clinical Investigation 122:4447–4460.
Weaver SC, Osorio JE, Livengood JA, Chen R, Stinchcomb DT Chikungunya virus and prospects for a vaccine Expert Review of Vaccines. Expert Review of Vaccines 11:1087–1101.
Symptoms
Transmission
Treatment & vs prevention