1. Beyond Glycolysis Page 174-177
Aerobic Respiration
Beyond Glycolysis
Page

2. Glycolysis review 1 Glucose + 2 ADP + 2 Pi + 2 NAD+ 
2 pyruvate + 2 ATP + 2 NADH +2 H+
All happens in the cytoplasm
Next step is to get the pyruvate into the mitochondria
Glycolysis review

3. Pyruvate Oxidation Mitochondria has two membranes
Pyruvate passively diffuses through the outer
Undergoes facilitated diffusion to go through inner
Once inside the mitochondrial matrix, pyruvate is acted upon by the pyruvate dehydrogenase complex
Complex catalyzes 3 reactions
Pyruvate Oxidation

4. Reaction 1:
Decarboxylation
A carbon is removed
Pyruvate Oxidation

5. Pyruvate Oxidation Reaction 2: Dehydrogenation
2 electrons and a proton are transferred to NAD+
Pyruvate Oxidation

6. Pyruvate Oxidation Reaction 3: RXN with CoA
Coenzyme A is added forming acetyl-CoA
Pyruvate Oxidation

7. Coenzyme A A derivative of ATP
All organisms sequenced to date encode enzymes for the synthesis of CoA
Also involved in synthesis and oxidation of fatty acids
Coenzyme A

8. Pyruvate oxidation

9. Pyruvate oxidation 2 pyruvate + 2 NAD+ + 2 CoA 
2 acetyl-CoA + 2 NADH + 2 H+ + 2 CO2
Pyruvate oxidation

10. Krebs cycle (citric acid cycle)