1. Cell division occurs in a series of stages, or phases.
Mitosis Notes
Cell division occurs in a series of stages, or phases.

2. 1st: INTERPHASE Cell is in normal function, nucleus is visible
Nuclear Membrane
Nucleolus
Cell is in normal function, nucleus is visible
Nuclear membrane is intact
Chromosomes are copied (# doubles)
Chromosomes appear as threadlike coils (chromatin) at the start, but each chromosome and its copy (sister chromosome) change to sister chromatids at end of this phase
Chromatin
Cell Membrane

3. 2nd: PROPHASE Mitosis begins (cell begins to divide)
Centrioles
Mitosis begins (cell begins to divide)
Nuclear membrane dissolves
Centrioles (or poles) appear and begin to move to opposite ends of cell
Spindle fibers form between the poles
Sister Chromatid
Spindle Fibers
Cell Membrane

4. 3rd: METAPHASE Sister Chromatid Centromeres Spindle Fibers Asters
Centrioles
Cell membrane
Chromatids (or pairs of chromosomes) attach to the spindle fibers
Spindle fibers line chromatids up in the middle of the cell

5. 4th: ANAPHASE
Chromatids (or pairs of chromosomes) separate and begin to move to opposite ends of the cell
Centrioles
Sister Chromatids
Spindle Fibers
Aster
Cell Membrane

6. 5th: TELOPHASE Two new nuclei form Chromosomes uncoil into chromatin
Nucleus
Cell Membrane pinches
Nuclear Membrane
Two new nuclei form
Chromosomes uncoil into chromatin
Cell membrane reforms and starts to pinch together
Mitosis Ends

7. 6th: CYTOKINESIS
Nucleolus
• Cell membrane moves inward to create two daughter cells - each with its own nucleus with identical chromosomes to the parent cell
Chromatin
Nuclear Membrane
Cell Membrane