1. Daily Warm-Up Thursday, January 9th
-Describe an operon
HW:
-Read 15.2
Turn In:
-Transformation lab questions if haven’t already

2. Gene Regulation and Cell Differentiation
20% of
protein-coding
DNA expressed
***Differential gene expression
-Cells have same genes
All organisms must regulate which genes are expressed in response to their internal and external environments.

3. Chromatin Structure and Gene Regulation
Histone Modifications and DNA Methylation
Acetylation (-COCH3) promotes transcription because opens chromatin up
Methylation decreases transcription because causes chromatin to condense

4. Epigenetics Inheritance of traits not based on DNA Nurturing rats
and behavior
-See link

5. Organization of Eukaryotic Gene and Control segments
Promoter and genes
Transcription Factors
Proteins needed for transcription
Control elements
Non-coding DNA that help transcription factors to bind

6. Control Elements Proximal Distal= ENHANCERS *video
Transcription factors (activators or repressors) bind to control elements
*video

7. Regulation besides Transcription
RNA processing
Alternative RNA splicing
mRNA degradation
Initiation of Translation
Protein processing and degradation