1. Cost-utility analysis of rufinamide versus topiramate and lamotrigine for the treatment of children with Lennox–Gastaut Syndrome in the United Kingdom 
Lara Verdian, Yunni Yi 
Seizure - European Journal of Epilepsy 
Volume 19, Issue 1, Pages 1-11 (January 2010)
DOI: /j.seizure
Copyright © 2009 British Epilepsy Association Terms and Conditions

2. Fig. 1
Markov decision analytic model structure. Abbreviations: RUF, rufinamide; TPM, topiramate; LTG, lamotrigine; WC75, drop attacks are really well controlled (≥75% reduction in drop attacks from baseline); WC50, drop attacks are well controlled (≥50% and <75% reduction in drop attacks from baseline); NC, non-responders where drop attacks are not well controlled (<50% reduction in drop attacks from baseline).
Seizure - European Journal of Epilepsy  , 1-11DOI: ( /j.seizure )
Copyright © 2009 British Epilepsy Association Terms and Conditions

3. Fig. 2
Cost-effectiveness plane comparing RUF with TPM and LTG. Abbreviations: RUF, rufinamide; TPM, topiramate; LTG, lamotrigine; QALYs, quality-adjusted life-years; GBP, Great British Pounds.
Seizure - European Journal of Epilepsy  , 1-11DOI: ( /j.seizure )
Copyright © 2009 British Epilepsy Association Terms and Conditions

4. Fig. 3
Uncertainty by covariates for RUF versus (A) TPM and (B) LTG in the base case scenario (TTO utilities) Abbreviation: QALYs, quality-adjusted life-years.
Seizure - European Journal of Epilepsy  , 1-11DOI: ( /j.seizure )
Copyright © 2009 British Epilepsy Association Terms and Conditions

5. Fig. 4
Cost-effectiveness acceptability curves for RUF, TPM and LTG using TTO utilities. Abbreviations: RUF, rufinamide; TPM, topiramate; LTG, lamotrigine; QALYs, quality-adjusted life-years; GBP, Great British Pounds.
Seizure - European Journal of Epilepsy  , 1-11DOI: ( /j.seizure )
Copyright © 2009 British Epilepsy Association Terms and Conditions

6. Fig. 5
One-way sensitivity analysis of RUF versus TPM. Abbreviations: RUF, rufinamide; TPM, topiramate; WC75, drop attacks are really well controlled (≥75% reduction in drop attacks from baseline); WC50, drop attacks are well controlled (≥50% and <75% reduction in drop attacks from baseline); NC, non-responders where drop attacks are not well controlled (<50% reduction in drop attacks from baseline); Tx, treatment.
Seizure - European Journal of Epilepsy  , 1-11DOI: ( /j.seizure )
Copyright © 2009 British Epilepsy Association Terms and Conditions

7. Fig. 6
One-way sensitivity analysis of RUF versus LTG. Abbreviations: RUF, rufinamide; LTG, lamotrigine; WC75, drop attacks are really well controlled (≥75% reduction in drop attacks from baseline); WC50, drop attacks are well controlled (≥50% and <75% reduction in drop attacks from baseline); NC, non-responders where drop attacks are not well controlled (<50% reduction in drop attacks from baseline).
Seizure - European Journal of Epilepsy  , 1-11DOI: ( /j.seizure )
Copyright © 2009 British Epilepsy Association Terms and Conditions