1. Volume 63, Issue 2, Pages 189-197 (February 2013)
A Randomized, Double-Blind, Dose-Finding, Multicenter, Phase 2 Study of Radium Chloride (Ra 223) in Patients with Bone Metastases and Castration-Resistant Prostate Cancer 
Christopher C. Parker, Sarah Pascoe, Aleš Chodacki, Joe M. O'Sullivan, Josep R. Germá, Charles Gillies O’Bryan-Tear, Trond Haider, Peter Hoskin 
European Urology 
Volume 63, Issue 2, Pages (February 2013)
DOI: /j.eururo
Copyright © 2012 European Association of Urology Terms and Conditions

2. Fig. 1
Study design. PSA=prostate-specific antigen; SRE=skeletal-related event; D=day; W=week; M=month.
European Urology  , DOI: ( /j.eururo )
Copyright © 2012 European Association of Urology Terms and Conditions

3. Fig. 2
Disposition of all randomized patients (Consolidated Standards of Reporting Trials diagram).
European Urology  , DOI: ( /j.eururo )
Copyright © 2012 European Association of Urology Terms and Conditions

4. Fig. 3
Median relative change from baseline in (A) prostate-specific antigen (PSA) and (B) bone alkaline phosphatase (ALP) for the per-protocol population. Arrows indicate the timing of each radium chloride Ra 223 injection. W=week.
European Urology  , DOI: ( /j.eururo )
Copyright © 2012 European Association of Urology Terms and Conditions

5. Fig. 4
Percentage of pain responders (pain index score ≤4) by dose group for patients with pain at baseline (per-protocol population).
European Urology  , DOI: ( /j.eururo )
Copyright © 2012 European Association of Urology Terms and Conditions

6. Fig. 5
Median hematologic values over time by dose group for (A) white blood cells, (B) neutrophils, (C) lymphocytes, (D) platelets, and (E) hemoglobin. The dotted line represents the value of grade 2 and 3 Common Terminology Criteria for Adverse Events. B=baseline; W=week; M=month.
European Urology  , DOI: ( /j.eururo )
Copyright © 2012 European Association of Urology Terms and Conditions

7. Fig. 6
Overall survival of patients receiving three injections of radium chloride Ra 223 at doses of 25, 50, or 80 kBq/kg (safety population); p=0.44 (log-rank) between groups for time to death.
European Urology  , DOI: ( /j.eururo )
Copyright © 2012 European Association of Urology Terms and Conditions