1. Challenges in Managing Progressive Multiple Sclerosis

3. Program Goals

4. Disclaimers

5. Overview

6. Progressive MS Onset, Mechanisms

7. Inflammation: A Target in Progressive MS?

8. Inflammation as a Target in Progressive MS: Therapeutic Lag?

9. PPMS Trials: Too Short or Too Late? UCSF Experience

10. Predicting Progression

11. Prognostic Profiling Possible Clinical Trial End Points

12. Clinical Trials in Progressive MS

13. Is There a Role for Rituximab? UCSF Experience

14. Is There a Role for Statins?

15. INFORMS -- What Did We Learn?

16. INFORMS -- What Did We Learn? (cont)

17. Laquinimod

18. B-Cell Therapies

19. Triamcinolone

20. Combination Therapy and Remyelination

21. Remyelination

22. Phenytoin in Optic Neuritis Proof-of-Concept Trial

23. Biotin in SPMS

24. Summary and Key Points

25. Abbreviations

26. Abbreviations (cont)

27. References

28. References (cont)

29. References (cont)

30. References (cont)

31. References (cont)

32. References (cont)