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Dun1 Counts on Rad53 to Be Turned On

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Presentation on theme: "Dun1 Counts on Rad53 to Be Turned On"— Presentation transcript:

1 Dun1 Counts on Rad53 to Be Turned On
Wei Zhang, Daniel Durocher  Molecular Cell  Volume 31, Issue 1, Pages 1-2 (July 2008) DOI: /j.molcel Copyright © 2008 Elsevier Inc. Terms and Conditions

2 Figure 1 The FHA Domains of Rad53 and Dun1 Act as Logic Gates
Rad53 and Dun1 paralogs require binding to the phosphorylated SCD1 motif of Rad53 (its amino acid sequence is depicted) for their respective activation. The binding behavior of the Rad53 FHA domain resembles an “OR” gate (depicted using the standard distinctive symbol), as it requires phosphorylation of either threonine 5 (pT5) or threonine 8 (pT8) residues on the SCD1 motif. By contrast, the binding behavior of Dun1 resembles an “AND” gate, as it requires diphosphorylation of the SCD1 motif. Molecular Cell  , 1-2DOI: ( /j.molcel ) Copyright © 2008 Elsevier Inc. Terms and Conditions

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