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Efficacy and safety of ivacaftor in patients with cystic fibrosis and a non-G551D gating mutation  Kris De Boeck, Anne Munck, Seth Walker, Albert Faro,

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Presentation on theme: "Efficacy and safety of ivacaftor in patients with cystic fibrosis and a non-G551D gating mutation  Kris De Boeck, Anne Munck, Seth Walker, Albert Faro,"— Presentation transcript:

1 Efficacy and safety of ivacaftor in patients with cystic fibrosis and a non-G551D gating mutation 
Kris De Boeck, Anne Munck, Seth Walker, Albert Faro, Peter Hiatt, Geoffrey Gilmartin, Mark Higgins  Journal of Cystic Fibrosis  Volume 13, Issue 6, Pages (December 2014) DOI: /j.jcf Copyright © 2014 European Cystic Fibrosis Society. Terms and Conditions

2 Fig. 1 Mean absolute change from baseline after 8weeks of treatment in (A) percent predicted FEV1; (B) BMI; (C) sweat chloride; and (D) CFQ-R respiratory domain score. BMI=body mass index; CFQ-R=Cystic Fibrosis Questionnaire-Revised. Journal of Cystic Fibrosis  , DOI: ( /j.jcf ) Copyright © 2014 European Cystic Fibrosis Society. Terms and Conditions

3 Fig. 2 Mean absolute change from baseline in percent predicted FEV1 over 24weeks of ivacaftor treatment for patients from treatment sequence 2 (placebo→ivacaftor). Journal of Cystic Fibrosis  , DOI: ( /j.jcf ) Copyright © 2014 European Cystic Fibrosis Society. Terms and Conditions

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