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Potential role of green tea catechins in the management of oxidative stress-associated infertility
Shubhadeep Roychoudhury, Ashok Agarwal, Gurpriya Virk, Chak-Lam Cho Reproductive BioMedicine Online Volume 34, Issue 5, Pages (May 2017) DOI: /j.rbmo Copyright © 2017 Reproductive Healthcare Ltd. Terms and Conditions
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Figure 1 Sources of oxidative stress and their impact on reproduction and fertility. Various endogenous as well as exogenous sources of ROS and the association between OS and pathological conditions in male and female reproduction. In the male, it has been shown to impair sperm function and/or cause sperm death, whereas in the female it is related to endometriosis, PCOS and other defects in the endometrium as well as embryo. Reproductive BioMedicine Online , DOI: ( /j.rbmo ) Copyright © 2017 Reproductive Healthcare Ltd. Terms and Conditions
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Figure 2 Principal catechin polyphenols in green tea. Most of the medicinal properties of green tea are associated with the four polyphenolic catechins: epicatechin (EC), epigallocatechin (EGC), epicatechin-3-gallate (ECG) and epigallocatechin-3-gallate (EGCG). The antioxidant as well as the ROS scavenging properties of these catechins are attributed to the presence of phenolic hydroxyl groups on the B-ring in EC and EGC, and in the B- and D-rings of ECG and EGCG. Reproductive BioMedicine Online , DOI: ( /j.rbmo ) Copyright © 2017 Reproductive Healthcare Ltd. Terms and Conditions
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Figure 3 Role of green tea extract and catechin polyphenols on reproductive functions and cellular mechanism of action. The figure indicates the possible cellular mechanism of action of green tea catechins via interactions with proteins and/or lipids in the plasma membrane, as well as apoptotic markers. It is postulated that through such interactions the green tea catechins are capable of improving semen, oocyte and embryo quality, thereby bringing about reduction in associated pathologies in the male and the female. Reproductive BioMedicine Online , DOI: ( /j.rbmo ) Copyright © 2017 Reproductive Healthcare Ltd. Terms and Conditions
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