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P27 and its ubiquitin ligase Skp2 expression in endometrium of IVF patients with repeated hormonal stimulation  Shirly Lahav-Baratz, Mara Koifman, Edmond.

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Presentation on theme: "P27 and its ubiquitin ligase Skp2 expression in endometrium of IVF patients with repeated hormonal stimulation  Shirly Lahav-Baratz, Mara Koifman, Edmond."— Presentation transcript:

1 p27 and its ubiquitin ligase Skp2 expression in endometrium of IVF patients with repeated hormonal stimulation  Shirly Lahav-Baratz, Mara Koifman, Edmond Sabo, Ron Auslender, Martha Dirnfeld  Reproductive BioMedicine Online  Volume 32, Issue 3, Pages (March 2016) DOI: /j.rbmo Copyright © 2015 Reproductive Healthcare Ltd. Terms and Conditions

2 Figure 1 Inverse relationship between p27 and Skp2 in the epithelial cells of the study group (IVF patients). n = 46; r = −0.58; P < Reproductive BioMedicine Online  , DOI: ( /j.rbmo ) Copyright © 2015 Reproductive Healthcare Ltd. Terms and Conditions

3 Figure 2 Immunohistochemical staining of p27 and Skp2 in endometrial cells of representative samples from the study group (IVF patients). Formalin-fixed paraffin-embedded tissues were stained as described in the Materials and methods. Samples are shown at ×200 magnification. Scale bar = 50 µm. Arrows mark stained cells. Prol = proliferative phase; Sec = secretory phase. Reproductive BioMedicine Online  , DOI: ( /j.rbmo ) Copyright © 2015 Reproductive Healthcare Ltd. Terms and Conditions

4 Figure 3 p27 and Skp2 in secretory endometrium in one case out of the eight in the study group (IVF patients) with high Skp2 concentrations compared with the control group (described in the text) and a control A patient (normal cycling woman). Formalin-fixed paraffin-embedded tissues were stained as described in the Materials and methods. Samples are shown at ×200 magnification. Scale bar = 50 µm. Arrows marked stained cells. Reproductive BioMedicine Online  , DOI: ( /j.rbmo ) Copyright © 2015 Reproductive Healthcare Ltd. Terms and Conditions

5 Figure 4 p27 and Skp2 in secretory endometrium in one case out of the eight in the study group (IVF patients) with high Skp2 concentrations compared with the control group (described in the text) and a control B patient (endometrial carcinoma patient). Formalin-fixed paraffin-embedded tissues were stained as described in the Materials and methods. Samples are shown at ×200 magnification. Scale bar = 50 µm. Arrows marked stained cells. EC = endometrial carcinoma; Sec = secretory phase. Reproductive BioMedicine Online  , DOI: ( /j.rbmo ) Copyright © 2015 Reproductive Healthcare Ltd. Terms and Conditions


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