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ADPr-ChAP: Mapping ADP-Ribosylation onto the Genome

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Presentation on theme: "ADPr-ChAP: Mapping ADP-Ribosylation onto the Genome"— Presentation transcript:

1 ADPr-ChAP: Mapping ADP-Ribosylation onto the Genome
Robert Lyle McPherson, Anthony K.L. Leung  Molecular Cell  Volume 61, Issue 3, Pages (February 2016) DOI: /j.molcel Copyright © 2016 Elsevier Inc. Terms and Conditions

2 Figure 1 ADP-Ribosylated Chromatin Affinity Precipitation (ADPr-ChAP) as a Method for Enriching and Analyzing Genome-wide ADP-Ribosylation Schematic representation of ADPr-ChAP workflow. ADP-ribosylated chromatin is bound and enriched by GST-tagged ADP-ribose (ADPr)-binding domain (e.g., WWE), and the associated DNA sequences are analyzed by high-throughput sequencing. For background information about ADP-ribosylation, the readers are referred to the Molecular Cell Special Issue on ADP-ribosylation, volume 58, issue 6 (2015). Molecular Cell  , DOI: ( /j.molcel ) Copyright © 2016 Elsevier Inc. Terms and Conditions

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